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. 2022 Aug 1;41(4-5):444–456. doi: 10.1007/s10930-022-10065-6

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Fig. 3 — Essential dynamics analysis of the wild-type and various variants, using the 100 ns simulation trajectories. The red to blue color of the backbone represents the starting and ending conformations, respectively. The extent of the backbone fluctuation is a measure of the amplitude of the motion. The higher amplitude of the dynamics correlates with the reduced binding affinity between RBD and ACE2 in these variants (Color figure online)