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. 2022 Jul 12;65(14):9858–9872. doi: 10.1021/acs.jmedchem.2c00505

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© 2022 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Characterization of pharmacokinetics of the Nectin-4/CD137 Bicycle TICAs in rats. (A) Plasma concentration–time profile of representative 1:1 Nectin-4/CD137 Bicycle TICAs BCY10000, BCY10572, or BCY12377 after being dosed intravenously (IV, bolus) at 2 mg/kg in SD rats. (B) Plasma concentration–time profile of representative 1:2 Nectin-4/CD137 Bicycle TICAs BCY12590, BCY10918, BCY11863, or BCY12587 after being dosed intravenously (IV, bolus) at 2 mg/kg in SD rats. (A, B) Data are mean ± SD (n = 3 animals/compound). (C) Clearance (CL), volume of distribution at a steady state (V_dss) and resulting terminal half-life for all Nectin-4/CD137 Bicycle TICAs assessed for pharmacokinetics in SD rats. Mean values are shown using crossbar with individual animal data as points on the plot.