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. 2022 Jul 15;65(14):9662–9677. doi: 10.1021/acs.jmedchem.2c00704

Scheme 3. Synthesis of Aminopyrimidine 46.

Scheme 3

Reagents and conditions: (a) NaH, iodomethane, THF, 0 °C, 94%; (b) TFA, DCM, rt; (c) 2-chloropyrimidin-4-amine, TEA, IPA, rt, 66%, over two steps.