Scheme 4. Synthesis of BLU-945 via Subsequent Buchwald–Hartwig Couplings.
Reagents and conditions: (a) 42, XantphosPd G4, Cs2CO3, 1,4-dioxane, 100 °C, 63%; (b) 46, BrettPhosPd G4, Cs2CO3, 1,4-dioxane, 100 °C, 38%.
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