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Kinetic characterization of the slow, tight-binding inhibition of AGTwt by compound 3. (A) Progression curves of pyruvate production during the reaction of AGTwt (0.05 μM) in the presence of l-alanine 250 mM, glyoxylate 10 mM, and compound 3 at the indicated concentrations in KP 0.1 M pH 7.4 at 25 °C for 50 min. Inset: plot of the kobs values obtained using eq 1 as a function of inhibitor concentration.
