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. Author manuscript; available in PMC: 2023 Jun 23.
Published in final edited form as: Cell. 2022 Jun 23;185(13):2213–2233.e25. doi: 10.1016/j.cell.2022.05.017

Figure 4. Enriched matrisome pathways by APOE4 in deconvoluted AD brain astrocytes.

Figure 4

(A)Upregulated pathways of DEGs comparing various trait of AD vs. control including APOE4 carriers in different brain regions. See Table S6 for brain cohort details.

(B) Functional pathway analysis of Matrisome in severe vs. mild AD from (A). See Table S3 for functional pathway statistics.

(C-J) fGSEA of APOE4 vs. APOE3 in each cell type after cell type deconvolution in various regions of AD brain (MSBB and ROSMAP). PFC, prefrontal cortex; STG, superior temporal gyrus; PHG, parahippocampal gyrus; IFG, inferior frontal gyrus; DLPFC, dorsolateral prefrontal cortex.

(K) Functional pathway analysis of Matrisome associated in APOE4 AD astrocytes after cell type deconvolution.

(L) Overlapping genes in Matrisome associated among iPSC-mixed cortical cultures, whole brain and deconvoluted astrocytes, and predicted functional co-regulations of overlapping genes.

(M-O) Functional pathway analysis of lipid pathways in APOE4 AD brain (MSBB) astrocytes (M) and microglia (N-O).