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. 2022 Jul 30;31:09636897221113803. doi: 10.1177/09636897221113803

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Full-thickness wounds and transplantation of ADM or recellularized ADM (Ai, ii). The presence of fibroblasts seeded on ADM was confirmed by analyzing recellularized ADM graft, 1 hour after transplantation. Arrows indicate cells attached to the surface of the ADM facing the wound bed (B.i, ii). Three weeks after transplantation, ADM-transplanted wound (C.i, ii) and recellularized ADM–transplanted wound (C.iii, iv) show engraftment to surrounding host tissue with complete epithelialization. However, in recellularized ADM group, high cellularity can be seen at the interface of graft/host tissue (arrow heads) (C.iv). Staining of the graft for pan-leukocyte marker, CD45, revealed that majority of the cells in the high-cellularity regions are CD45+ cells. (D.i, ii). Figures are representatives from 3 mice (n = 3). ADM: acellular dermal matrix.