TABLE 4.
GRADE profile of included studies investigating the effects of l-arginine supplementation on blood pressure in adults1
| Summary of findings | ||||||||
|---|---|---|---|---|---|---|---|---|
| Quality assessment | Number of | |||||||
| Outcomes | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | intervention/control | WMD (95% CI) | Quality of evidence5 |
| SBP | No serious limitations | Very serious limitations2 | Serious limitations3 | No serious limitations | No serious limitations | 431/394 | −6.40 (−8.74, −4.05) | ⊕⊕◯◯ Low |
| DBP | No serious limitations | Very serious limitations4 | Serious limitations3 | No serious limitations | No serious limitations | 392/361 | −2.66 (−3.93, −1.39) | ⊕⊕◯◯ Low |
1
DBP, diastolic blood pressure; GRADE, Grading of Recommendations Assessment, Development, and Evaluation; SBP, systolic blood pressure; WMD, weighted mean difference.
2
The test for heterogeneity is significant, and the I2 is moderate, 90.4%.
3
Studies conducted in participants with various conditions.
4
The test for heterogeneity is significant, and the I2 is moderate, 84.0%
5
⊕ symbol shows +1 quality evidence; for every serious limitation, one of this quality evidence is lost and changes to ◯ symbol; ⊕⊕◯◯: low (The true effect may differ significantly from the estimate).