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. 2022 Aug 1;30(10):1432–1442.e4. doi: 10.1016/j.str.2022.07.005

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Binding of eACE2 and hACE2 to SARS-CoV-2 variants

(A) The variant change ratio in binding activity, determined by measuring the mean fluorescence intensity (MFI) relative to that of WT D614G. Values over 100% indicate an increase, and those lower than 100% indicate a decrease. Results were calculated from two independent experiments performed in technical duplicates (n = 2) and represent mean ± SD. pVOC, previous variant of concern; pVOI, previous variant of interest. See also Figure S3.

(B) The binding affinities of horse or human ACE2 for the RBDs of SARS-CoV-2 variants are summarized. Horse or human ACE2 was immobilized on the CM5 chip, and RBDs were flowed through. See also Figure S4.