Table 2.
Genotypes and phenotypes frequencies of Duffy blood group among P. vivax infected patients in East Shewa, Ethiopia
| DbSNP | rs2814778 | rs12075 | rs34599082 | rs13962 | Predicted genotype | Predicted antigen | Phenotype | No. (%) |
|---|---|---|---|---|---|---|---|---|
| Nucleotide | c.1-67a | c.125b | c.265c | c.298d | ||||
| Region | 5′UTR | Exon 2 | Exon 2 | Exon 2 | ||||
| SNP (amino acid) | C | A(Asp42) | C(Arg89) | G(Ala100) | FY*BES/FY*BES or FY*02 N.01/FY*02 N.01 | Fyes/Fyes | Fy(a − b −) | 4 (2.9) |
| T | G(Gly42) | C(Arg89) | G(Ala100) | FY*A/FY*A or FY*01/FY*01 | Fya | Fy(a + b −) | 7 (5.1) | |
| A(Asp42) | C(Arg89) | G(Ala100) | FY*B/FY*B or FY*02/FY*02 | Fyb | Fy(a − b +) | 6 (4.3) | ||
| G(Gly42)/A(Asp42) | C(Arg89) | G(Ala100) | FY*A/FY*B or FY*01/FY*02 | Fya/Fyb | Fy(a + b +) | 17 (12.3) | ||
| C/T | A(Asp42) | C(Arg89) | G(Ala100) | FY*B/FY*BES or FY*02/FY*02 N.01 | Fyb/Fyes | Fy(a − b +) | 67 (48.6) | |
| A(Asp42) | C(Arg89) | A(Thr100) | FY*02/FY*02 N.01 | Fyb/Fyes | Fy(a − b +) | 1 (0.7) | ||
| A(Asp42) | C(Arg89)/T(Cys89) | G(Ala100)/A(Thr100) | FY*BES/FY*X or FY*02 W.01/FY*02 N.01 | Fyx/Fyes | Fy(a − b +) | 1 (0.7) | ||
| G(Gly42)/A(Asp42) | C(Arg89) | G(Ala100) | FY*A/FY*BES or FY*01/FY*02 N.01 | Fya/Fyes | Fy(a + b −) | 35 (25.4) |
NB: the nucleotide position (dbSNP) is based on NCBI data, UTR: untranslated region
aThis polymorphism prevents expression of Fyb antigen in red blood cells
bThis polymorphism predicts the expression of the Fya and Fyb antigens
c,dThese polymorphisms determine weak expression of the Fyb antigen