TABLE I.

Rated Contrast Subgroups and Ratio of Published Significant Genes

Subgroup 1 a			Subgroup 2		No. of Discovered Genes	No. of Discovered Genes also in AutDB b	No. of PubMed Articles
Population Variable(s)	Cohort Size		Population Variable(s)	Cohort Size	Number	Number	Number
Low SSC Full Scale IQ	459	vs	High SSC Full Scale IQ	373	5	1	2242
Normal to Speak Sentences	346	vs	Late to Speak Sentences	304	16	3	5130
Mid RBS-R Overall Score AND Low CBCL6 Social Score	202	vs	Low RBS-R Overall Score AND Low CBCL6 Social Score	77	44	6	898
Low ABC III Stereotypy Scale AND Late to Use Words	171	vs	High ABC III Stereotypy Scale AND Late to Use Words	159	18	2	452
Mid Vineland II Daily Living AND High Height Z Score AND High ADIR C Total	253	vs	High Vineland II Daily Living AND High Height Z Score AND High ADIR C Total	54	22	4	0
Mid CBCL6 Rule Breaking Score AND Low CBCL6 Activities Score AND High SRS-P Total Score	228	vs	High CBCL6 Rule Breaking Score AND Low CBCL6 Activities Score AND High SRS-P Total Score	59	25	4	0

SSC Full Scale IQ = Simons Simplex Complex Full Scale IQ, RBS-R = Repetitive Behaviors Scale-Revised, CBCL6 = Child Behavior Checklist for ages 6-18, ABC III = Aberrant Behavior Checklist-Stereotype Scale, Vineland II Daily Living = Vineland Adaptive Behavior Scales-Second Edition in Daily Living domain, ADIR C Total = Autism Diagnostic Interview-Revised (ADI-R)-Restricted, Repetitive, and Stereotyped Patterns of Behavior total score, SRS-P = Social Responsiveness Scale – Parent Report.

Details about significant genes are in the Supplement 1.