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Brown adipose tissue mediates cardiac function via thermogenic and endocrine action. Abbreviations: β-AR, β-adrenergic receptors; iBAT, intrascapular brown adipose tissue; TAG, triacylglycerol; FA, fatty acid; ERK, extracellular-signal-regulated kinase; AKT, protein kinase B; IL6, interleukin 6; FGF21, fibroblast growth factor 21; CM, cardiomyocyte.
