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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Nat Immunol. 2021 Aug 23;22(9):1163–1174. doi: 10.1038/s41590-021-01001-4

Extended Data Figure 5 |. Restoration of Foxp3 expression in Treg “wannabes” in mosaic adult female Foxp3LSL/DTR-GFP mice suppresses immune activation caused by diphtheria toxin-mediated Treg cell ablation.

Extended Data Figure 5 |

Experimental scheme shown in Figure 2a. a, Representative histograms showing expression of activation and proliferation markers in splenic conventional T cell populations. b, Representative contour plots of splenic conventional CD4 and CD8 T cells showing cytokine production. c, Percentages (left) and numbers (right) of Treg and Treg “wannabes” from indicated tissues 5 weeks post 4-OHT administration. Two-way ANOVA with Tukey’s multiple comparison test. All error bars denote mean ± s.e.m. ns, non-significant; *, p<0.05; **, p<0.01; ***, p<0.001; ****, p<0.0001. pLN, peripheral (brachial, axillary, and inguinal) lymph nodes; mLN, mesenteric lymph nodes; LP, lamina propria.