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. 2022 Jul 28;14(1):2102878. doi: 10.1080/19490976.2022.2102878

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Host metabolic homeostasis and neurological impact.

The portal metabolome reflects the intestinal metabolism of dietary compounds. After processing by the liver, a pool of metabolites will reach the systemic circulation. The systemic metabolome is a dynamic metabolic signature reflecting the interaction between the diet, gut microbiota, liver, and other organs. Metabolites can influence the functioning of all organs, including the brain by modulating a range of metabolic pathways related to neurological functions. (Figure created with Biorender.com)