Table 3.
Model evaluations for measured responses.
| Response | R2 | Adjusted R2 | Predicated R2 | Adequate precision | Significant factors |
|---|---|---|---|---|---|
| EE % | 0.9908 | 0.9883 | 0.9788 | 70.440 | A, B, C, C2 |
| PS (nm) | 0.8947 | 0.8750 | 0.8547 | 22.650 | A, B, C |
| ZP (mV) | 0.9320 | 0.9192 | 0.8949 | 28.473 | A, B, C |
| Q8h (%) | 0.9223 | 0.9132 | 0.8986 | 32.395 | A, C |
Abbreviations: EE %, percent entrapment efficiency; PS, particle size; Q8h, percent drug released after 8 hours; ZP, zeta potential.