Table 2.
Cytokine production by PBMC, after 72 h cultures against M. leprae stimulus.
| Cytokynes (pg/mL) | T1R | BL | p value | T2R | LL | p-value | |
|---|---|---|---|---|---|---|---|
| Mean ±SD | Mean ±SD | Mean ±SD | Mean ±SD | ||||
| IL-17 | UNS | 223.2 ± 41.3 | 176.4 ± 42.3 | – | 560.1 ± 299.3 | 207.5 ± 85.2 | * |
| ML | 341.1 ± 80.8 | 196.1 ± 77.9 | – | 763.7 ± 316.8 | 295.4 ± 89.6 | * | |
| IL-23 | UNS | 137.7 ± 11.7 | 138.1 ± 13.1 | – | 207.9 ± 85.4 | 203.6 ± 81.1 | – |
| ML | 129.8 ± 4.7 | 140.3 ± 9.7 | – | 191.7 ± 73.6 | 225.5 ± 74.3 | – | |
| IL-6 | UNS | 28.3 ± 7.7 | 20.3 ± 4.6 | – | 30.1 ± 1.8 | 27.1 ± 1.3 | ** |
| ML | 20.5 ± 8.7 | 19.7 ± 5.3 | – | 29.9 ± 1.1 | 25.9 ± 2.3 | ** | |
| IFN-γ | UNS | 130.8 ± 46.7 | 89.6 ± 14.8 | – | 153.6 ± 36.5 | 139.9 ± 33.7 | – |
| ML | 142.5 ± 24.7 | 107.5 ± 34 | – | 147.2 ± 27.3 | 139.7 ± 40.9 | – | |
| IL-10 | UNS | 176.6 ± 10.9 | 157.8 ± 10.5 | – | 94.1 ± 39.4 | 137.7 ± 49.3 | – |
| ML | 165.3 ± 30.2 | 160.3 ± 11.1 | – | 69.7 ± 24.5 | 88.6 ± 39.8 | – | |
The results were expressed as mean and standard deviation. The Mann-Whitney was used for statistical analysis where, *p ≤ 0.05, **p ≤ 0.01. T1R, Type 1 reaction; BL, borderline lepromatous; T2R, Type 2 reaction; LL, polar lepromatous patients; SD, standard deviation; UNS, unstimulated; ML, M. leprae stimulus. It was analyzed BL 7, T1R 3, LL 10 and T2R 10 individuals.