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. 2022 Jul 18;13:923031. doi: 10.3389/fimmu.2022.923031

Figure 4.

Figure 4

Discrimination and calibration of hepatocellular carcinoma (HCC) prediction models via proteomics analyses in the training dataset. (A) Receiver operating characteristic (ROC) curves and area under the curve (AUC) in the SPINK1, SPINK1 plus alpha-fetoprotein (AFP), and AFP models. (B–D) Calibration curves of AFP (B), SPINK1 (C), and SPINK1+AFP (D). (E) Comparison of the decision curve analysis (DCA) of SPINK1, SPINK1+AFP, and AFP in terms of clinical net benefits. (F–H) Clinical benefits obtained from the clinical impact curve (CIC) analysis of each detection model.