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. 2022 Jul;32(7):1343–1354. doi: 10.1101/gr.276042.121

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© 2022 Mikulasova et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 3. — Chromatin landscape of the CCND1 locus in five cell lines derived from B cell hematological malignancies. The upper line of each cell line (Supplemental Table S3) represents the selected ChIP-seq chromatin states (Supplemental Table S1), and the lower line shows DNase I hypersensitivity sites for the nonvariable region of the IGH locus. The vertical black line in U266 marks position of the inserted Eα1 super-enhancer. The breakpoints within the IGH locus are characterized in Supplemental Figure S5. Shaded-purple arrows symbolize translocation orientation. Numbers in colored squares (red denotes high expression; blue, low expression) show CCND1 expression detected using RNA-seq in fragments per kilobase of transcript per million mapped reads (FPKM). (PC) Polycomb, (P) promoter.