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. 2022 Jun 26;13(6):14357–14367. doi: 10.1080/21655979.2022.2085391

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — TLR3 promotes the proliferation, migration, invasion, and EMT of human LECs by directly acting on the Jagged-1/Notch signaling pathway. The TGF-β2 treated SRA01/04 cells were treated with si-TLR3, Notch pathway activator valproic acid (VA) and inhibitor DAPT. Next, (a) qRT-PCR is used to detect the gene expression levels of FN, α-SMA, Col I, and E-cad in each group. (b) CCK-8 method is used to detect the cell viability in each group. (c-d) Transwell method is used to detect the cell migration and invasion abilities of LECs in each group. (e) Western blotting is used to detect the expression levels of EMT-related proteins and Jagged-1/Notch signaling pathway-related proteins in each group. **P< 0.01, ***P< 0.001 vs Control. ^##P< 0.01, ^###P< 0.001 vs. TGF-β2+ si-nc, ^&P< 0.05, ^&&P< 0.01 vs TGF-β2+ si-TLR3 group.