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. 2022 Jun 26;13(6):14313–14328. doi: 10.1080/21655979.2022.2084257

Figure 3.

Figure 3.

Circ_0078767 targets miR-889.

(a). The binding site of miR-889 to circ_0078767 was predicted employing the Circular RNA Interactome database.(b). The targeted relationship of miR-889 with circ_0078767 was verified through dual-luciferase reporter gene assay.(c&d). The direct interaction between miR-889 and circ_0078767 was verified via RIP assay.(e). RNA pull-down assay explored the interaction between circ_0078767 and miR-889.(f). Detection via qRT-PCR of miR-889 expression in Saos2 and MG63 cells with circ_0078767 overexpression or knockdown.(g&h). Detection of miR-889 expression in OS tissues and cells via qRT-PCR.(i). Pearson correlation analysis of the correlation of circ_0078767 with miR-889 expression in OS tissues.Each experiment was performed in triplicate. *P < 0.05, **P < 0.01, ***P < 0.001.