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. 2022 Jun 26;13(6):14159–14174. doi: 10.1080/21655979.2022.2083855

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Graphic representation of the role of the miR-331-3p/MGAT1 axis in OS malignancy. MiR-331-3p suppressed MGAT1 expression, which resulted in decreased c-myc and Cyclin D1 proteins and decreased OS cells proliferation ability. MiR-331-3p decreased MGAT1 expression, which resulted in an increase in Bax and a decrease in Bcl-2, which was associated with an increase in OS cells apoptosis. Furthermore, miR-331-3p reduced MGAT1 expression levelby interacting with MGAT1 3’UTR, which resulted in decreased EMT, leading to a reduction in OS cells migration, invasion and metastasis capacities.