Table 4.
Genotype Frequency Distributions Between Lung Cancer Cases and Healthy Controls
| Model | Genotype | Control | Case | OR (95% CI) | p |
|---|---|---|---|---|---|
| rs2233914 | GG | 290 (44.6%) | 269 (41.4%) | 1 | 0.47 |
| GA | 287 (44.1%) | 308 (47.4%) | 1.15 (0.92–1.46) | ||
| AA | 73 (11.2%) | 73 (11.2%) | 1.08 (0.75–1.55) | ||
| rs10981694 | TT | 438 (67.4%) | 377 (58%) | 1 | 0.0005* |
| TG | 197 (30.3%) | 240 (36.9%) | 1.44 (1.12–1.84) | ||
| GG | 15 (2.3%) | 33 (5.1%) | 2.57 (1.37–4.82) | ||
| rs10488764 | GG | 392 (60.3%) | 318 (48.9%) | 1 | <0.0001* |
| GA | 222 (34.1%) | 271 (41.7%) | 1.52 (1.21–1.92) | ||
| AA | 36 (5.5%) | 61 (9.4%) | 2.15 (1.39–3.34) | ||
| rs1061472 | TT | 242 (37.2%) | 226 (34.8%) | 1 | 0.67 |
| TC | 302 (46.5%) | 314 (48.3%) | 1.11 (0.87–1.42) | ||
| CC | 106 (16.3%) | 110 (16.9%) | 1.10 (0.80–1.53) | ||
| rs9535826 | TT | 224 (34.5%) | 291 (44.8%) | 1 | 0.0002* |
| TG | 329 (50.6%) | 296 (45.5%) | 0.69 (0.55–0.88) | ||
| GG | 97 (14.9%) | 63 (9.7%) | 0.50 (0.35–0.72) | ||
| rs9535828 | GG | 207 (31.9%) | 285 (43.9%) | 1 | <0.0001* |
| GA | 324 (49.9%) | 287 (44.1%) | 0.49 (0.37–0.64) | ||
| AA | 119 (18.3%) | 78 (12%) | 0.30 (0.20–0.45) |
Note: *Bonferroni multiple adjustment was applied, with p ≤ 0.008.
Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval.