. 2022 Jul 26;15:733–742. doi: 10.2147/PGPM.S372824

Table 5.

Association Between SNPs and Risk of Lung Cancer in Genetic Models

SNP	Model	Genotype	Control	Case	OR (95% CI)	p
rs2233914	Dominant	GG	290 (44.6%)	269 (41.4%)	1	0.250
	Dominant	GA-AA	360 (55.4%)	381 (58.6%)	1.14 (0.91–1.42)	0.250
	Recessive	GG-GA	577 (88.8%)	577 (88.8%)	1	1.000
	Recessive	AA	73 (11.2%)	73 (11.2%)	1.00 (0.71–1.41)	1.000
	Log-additive	—	—	—	1.08 (0.91–1.27)	0.390
rs10981694	Dominant	TT	438 (67.4%)	377 (58%)	1	0.0005*
	Dominant	TG-GG	212 (32.6%)	273 (42%)	1.52 (1.20–1.93)	0.0005*
	Recessive	TT-TG	635 (97.7%)	617 (94.9%)	1	0.0085*
	Recessive	GG	15 (2.3%)	33 (5.1%)	2.24 (1.20–4.16)	0.0085*
	Log-additive	—	—	—	1.50 (1.22–1.84)	0.0001*
rs10488764	Dominant	GG	392 (60.3%)	318 (48.9%)	1	<0.0001*
	Dominant	GA-AA	258 (39.7%)	332 (51.1%)	1.61 (1.29–2.01)	<0.0001*
	Recessive	GG-GA	614 (94.5%)	589 (90.6%)	1	0.006*
	Recessive	AA	36 (5.5%)	61 (9.4%)	1.81 (1.18–2.78)	0.006*
	Log-additive	—	—	—	1.49 (1.25–1.78)	<0.0001*
rs1061472	Dominant	TT	242 (37.2%)	226 (34.8%)	1	0.370
	Dominant	TC-CC	408 (62.8%)	424 (65.2%)	1.11 (0.88–1.39)	0.370
	Recessive	TT-TC	544 (83.7%)	540 (83.1%)	1	0.790
	Recessive	CC	106 (16.3%)	110 (16.9%)	1.04 (0.78–1.39)	0.790
	Log-additive	—	—	—	1.06 (0.91–1.24)	0.450
rs9535826	Dominant	TT	224 (34.5%)	291 (44.8%)	1	0.0002*
	Dominant	TG-GG	426 (65.5%)	359 (55.2%)	0.65 (0.52–0.81)	0.0002*
	Recessive	TT-TG	553 (85.1%)	587 (90.3%)	1	0.0043*
	Recessive	GG	97 (14.9%)	63 (9.7%)	0.61 (0.44–0.86)	0.0043*
	Log-additive	—	—	—	0.70 (0.60–0.83)	<0.0001*
rs9535828	Dominant	GG	207 (31.9%)	285 (43.9%)	1	<0.0001*
	Dominant	GA-AA	443 (68.2%)	365 (56.1%)	0.46 (0.35–0.60)	<0.0001*
	Recessive	GG-GA	531 (81.7%)	572 (88%)	1	0.0002*
	Recessive	AA	119 (18.3%)	78 (12%)	0.53 (0.38–0.74)	0.0002*
	Log-additive	—	—	—	0.54 (0.44–0.65)	<0.0001*

Note: *Bonferroni multiple adjustment was applied, with p ≤ 0.008.

Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval.