Table 7.

Association Between rs10981694, rs10488764, rs9535826 and rs9535828 and Risk of Different Pathological Types of Lung Cancer

SNP	Model	Genotype	Adenocarcinoma		Squamous Cell Carcinoma		Small Cell Lung Cancer
			OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
rs10981694	Dominant	TT	1	0.048	1	0.0001*	1	0.024
		TG-GG	1.35 (1.00–1.81)		2.06 (1.44–2.96)		1.67 (1.07–2.59)
	Recessive	TT-TG	1	0.027	1	0.07	1	0.015
		GG	2.31 (1.11–4.83)		2.21 (0.96–5.09)		3.26 (1.34–7.93)
	Log-additive	—	1.37 (1.07–1.77)	0.014	1.86 (1.38–2.53)	0.0001*	1.70 (1.18–2.46)	0.005*
rs10488764	Dominant	GG	1	0.0021*	1	0.0098	1	0.0006*
		GA-AA	1.55 (1.17–2.05)		1.53 (1.11–2.12)		2.00 (1.34–2.96)
	Recessive	GG-GA	1	0.22	1	0.0006*	1	0.058
		AA	1.42 (0.82–2.45)		2.70 (1.56–4.68)		1.97 (1.01–3.85)
	Log-additive	—	1.40 (1.12–1.75)	0.003*	1.56 (1.22–2.00)	0.0005*	1.72 (1.27–2.31)	0.0005*
rs9535826	Dominant	TT	1	0.0013*	1	0.18	1	0.0048*
		TG-GG	0.63 (0.47–0.83)		0.80 (0.57–1.11)		0.56 (0.38–0.84)
	Recessive	TT-TG	1	0.006*	1	0.29	1	0.015
		GG	0.54 (0.34–0.85)		0.77 (0.47–1.26)		0.44 (0.22–0.91)
	Log-additive	—	0.67 (0.54–0.83)	0.0002*	0.83 (0.65–1.06)	0.13	0.60 (0.44–0.82)	0.0011*
rs9535828	Dominant	GG	1	<0.0001*	1	0.0022*	1	<0.0001*
		GA-AA	0.46 (0.33–0.64)		0.52 (0.34–0.79)		0.36 (0.22–0.59)
	Recessive	GG-GA	1	0.0041*	1	0.0035*	1	0.049
		AA	0.55 (0.36–0.84)		0.48 (0.28–0.80)		0.53 (0.27–1.03)
	Log-additive	—	0.55 (0.43–0.71)	<0.0001*	0.52 (0.38–0.72)	<0.0001*	0.46 (0.31–0.67)	<0.0001*

Note: *Bonferroni multiple adjustment was applied, with p ≤ 0.008.

Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval.