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Different expression patterns of VRAC subunits in the nephron
| VRAC Subunit | Glomerulus | Proximal Tubule | Thick Ascending Limb | Distal Tubule | Cortical Collecting Duct |
|---|---|---|---|---|---|
| LRRC8A | +++ | +++ | + | + | + (ICs and PCs) |
| LRRC8B | ++ | +++ | + | − | − |
| LRRC8C | +++ | − | − | − | − |
| LRRC8D | − | +++ | + | + | + (ICs and PCs) |
| LRRC8E | − | − | − | − | +++ (ICs) |
Qualitative estimation of abundance from highest (+++) to absence (−). IC, intercalated cell; PC, principal cell.
