Table 2.
Composition of the Prepared GEF-SLN and GEF-P-SLN
| Formulation Code | SA | PF-68 | TPGS | GEF |
|---|---|---|---|---|
| GEF-SLN1 | 1000 | 200 | 0 | 10 |
| GEF-SLN2 | 1000 | 200 | 0 | 20 |
| GEF-SLN3 | 1000 | 200 | 0 | 30 |
| GEF-SLN4 | 1000 | 200 | 0 | 40 |
| GEF-SLN5 | 800 | 200 | 0 | 40 |
| GEF-SLN6 | 600 | 200 | 0 | 40 |
| GEF-P-SLN | 1000 | 200 | 20 | 40 |
Notes: The amount was expressed in mg unit. In all formulations, the predetermined amount of surfactant was dissolved in 20 mL distilled water as a continuous phase.
Abbreviations: GEF-P-SLN, gefitinib-loaded PEGylated solid lipid nanoparticle; SA, stearic acid; PF-68, Pluronic F-68; TPGS, D-α-Tocopherol polyethylene glycol 1000 succinate; GEF, gefitinib.