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. 2022 Jul 18;10:911551. doi: 10.3389/fpubh.2022.911551

Figure 3.

Figure 3

Differential IP-10 mRNA and protein expression in hepatic tissue and cultured Huh7 cells. (A) Intrahepatic IP-10 and CXCR3 mRNA expression in HCV-infected patients was higher than in HCs, and it was higher in HAI >4 subgroup than in HAI ≤ 4 subgroups (p < 0.001); (B) Intrahepatic IP-10 and CXCR3 protein expression in HCV-infected patients was higher than in HCs, and it was higher in HAI >4 subgroup than in HAI ≤ 4 subgroup too (p < 0.001). (C) The level of IP-10 concentration in cell culture supernatants was the highest in HCV-replicated-Huh7 cells (p < 0.001), but it can be mostly restored by NS5A inhibitor. (D,E) Expression of IP-10 mRNA and protein in cultured Huh7 cells, with the highest in HCV-replicated-Huh7 cells, can also be mostly restored by NS5A inhibitor. (F) The representative immunoblotting band for IP-10 protein in HCV-replicated-Huh7 cells; the results of visual effects are consistent with the data expression of E.