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. 2022 Jul 18;13:930287. doi: 10.3389/fimmu.2022.930287

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Copyright © 2022 Akoolo, Djokic, Rocha, Ulloa and Parveen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of EA treatment on cytokines production by CD4+ Th1 and Th2 cells in serum, spleen, and heart extracts of Borrelia burgdorferi-infected C3H/HeJ male mice. IL-4, IL-5, and IL-13 cytokines that are primarily produced by Th2 cells were reduced significantly in heart after EA treatment while proinflammatory Type II IFN-γ cytokines were reduced significantly in heart as well as spleen. Overall lower levels of these cytokines were detected by LEGENDplex in EA-treated mice in this study. Bars indicate median values. Statistical analysis was conducted using two-tailed unpaired Student’s t-tests for unequal variance to determine significant difference between the paired groups (NS-Not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). EA, electroacupuncture.