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| Hemoglobin < 10 g/dL |
| B-symptoms |
| Platelets < 100 U/L |
| Bulky adenopathy (> 5 cm in maximum diameter or causing symptoms) |
| Symptomatic hepatomegaly or splenomegaly |
| Presence of light chain amyloidosis |
| Symptomatic hyperviscosity |
| Symptomatic cryoglobulinemia |
| Symptomatic cold agglutinin anemia |
| Neuropathy due to WM |
| Amyloidosis due to WM |
Note. Information from Dimopoulos & Kastritis (2019).
