Table 5. Workup for Waldenström Macroglobulinemia.

General workup

CBC

CMP

LDH

Disease-specific labs

B2M

SPEP

UPEP

Free light chains

IgG, IgA, IgM

Cold agglutinin titer

Viscosity

Cryoglobulin

Cryocrit

Myelin-associated glycoprotein (if neuropathy present)

Coagulation studies

Partial thromboplastin time

Prothrombin time

Von Willebrand

Imaging

CT chest, abdomen, and pelvis

PET-CT

Pathology

Bone marrow biopsy with flow cytometry

Mutation panel: MYD88 and CXCR4

Note. CBC = complete blood count; CMP = comprehensive metabolic panel; LDH = lactate dehydrogenase; B2M = beta-2 microglobulin; SPEP = serum protein electrophoresis; UPEP = urine protein electrophoresis.