Table 8. Amyloidosis Staging System (Mayo 2012 Model).
Stage | Troponin T (μg/L) or hs-cTnT (ng/L) | NT-proBNP (ng/L) | Difference between involved and uninvolved (mg/dL) | Prognosis in patients not undergoing AuSCT (mo) | Prognosis in patients undergoing AuSCT (mo) |
---|---|---|---|---|---|
I | < 0.025 μg/L | < 1,800 | < 18 | 55 | NR |
II | Any one factor elevated | 19 | 62.8 | ||
III | Any two factors elevated | 12 | 16.8 | ||
IV | > 0.025 μg/L OR ≥ 40 ng/L |
> 1,800 | > 18 | 5 | 5.8 |
Note. hs-cTnT = high-sensitive cardiac troponin T; NT-proBNP = N-terminal of the prohormone brain natriuretic peptide; AuSCT = autologous stem cell transplant; OR = overall response. Adapted from Kumar et al. (2012a); Muchtar et al. (2018).