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. 2022 Jul 28;13(Suppl 4):45–56. doi: 10.6004/jadpro.2022.13.5.14

Table 8. Amyloidosis Staging System (Mayo 2012 Model).

Stage Troponin T (μg/L) or hs-cTnT (ng/L) NT-proBNP (ng/L) Difference between involved and uninvolved (mg/dL) Prognosis in patients not undergoing AuSCT (mo) Prognosis in patients undergoing AuSCT (mo)
I < 0.025 μg/L < 1,800 < 18 55 NR
II Any one factor elevated 19 62.8
III Any two factors elevated 12 16.8
IV > 0.025 μg/L OR
≥ 40 ng/L
> 1,800 > 18 5 5.8

Note. hs-cTnT = high-sensitive cardiac troponin T; NT-proBNP = N-terminal of the prohormone brain natriuretic peptide; AuSCT = autologous stem cell transplant; OR = overall response. Adapted from Kumar et al. (2012a); Muchtar et al. (2018).