Skip to main content
. 2022 Jul 4;11:e75253. doi: 10.7554/eLife.75253

Figure 5. Surgical removal of M1 does not abolish therapeutic benefit of subthalamic nucleus deep brain stimulation (STN DBS).

Figure 5.

(A) Left: Sagittal schematic showing STN DBS and M1 surgical lesion. Right: Postmortem sagittal section showing estimated extent of M1 lesion (inset, scale = 500 μm). (B) Representative single-session velocity of an M1-lesioned hemiparkinsonian mouse in response to 100 Hz STN DBS. (C) Average velocity before, during, and after 100 Hz STN DBS in M1-lesioned hemiparkinsonian mice (N=11 mice). Statistical significance was determined using a one-way repeated measures ANOVA with a Tukey HSD post hoc analysis applied to correct for multiple comparisons; **p < 0.01 (only comparison between pre and stim shown, see Supplementary file 1, table 1 for detailed statistics). Arrowhead in velocity trace corresponds to 1 cm/s. Bar plots show mean ± SEM.