Figure 5.

Preclinical PET imaging and analysis of mice coinjected with PBS, AFB Nb70 and Nb11-59. (a) Preclinical PET imaging of ⁶⁸Ga-Nb1159 i.v. coinjected with PBS, a negative control nanobody and Nb11-59 in KM mice after subcutaneous injection of the RBD. The white arrow indicates the subcutaneous injection of the RBD. (b) Comparison of SUVmax in three groups of mice coinjected with PBS (n = 4), a negative control nanobody (n = 5, 1 mg per mouse i.v.), and Nb11-59 (n = 3, 1 mg per mouse i.v.). (c) The correlation of SUVmax and Nb11-59 amount coinjected with the agent.