FIG. 3.

Involvement of CAP1 in C. albicans MDR and OSR. Strains CAI4/PMK, CJD21/PMK, CJD21/PMK-CAP1, and CJD21/PMK-CAP1TR were analyzed by spot assay (as described in Materials and Methods) for the ability to grow on YPD plates containing different antifungal (A) and prooxidant (B) agents. Growth differences were monitored after 2 days at 30°C. A representative plate of control growth on YPD medium is shown for each set of experiments (YPD). Abbreviations for substances are FCZ (fluconazole), Cer (cerulenin), Brf (brefeldin A), Cd (cadmium), 4-NQO (4-nitroquinoline N-oxide), and Phe (1,10-phenanthroline).