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. 2021 Mar 17;38(4):577–590. doi: 10.1007/s10565-021-09597-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Downregulated miR-21-5p in M2 macrophage-derived EVs disrupts tumorigenesis of PaCa in mice. a Subcutaneous xenografted tumors in nude mice, b tumor volume growth curve, c tumor weight, and d immunohistochemistry of Nanog and Oct4 expression. &P < 0.05 compared with the control group; *P < 0.05 compared with the NC-EV group; #P < 0.05 compared with the miR-21-5p-EV group. N = 5; The data were expressed as mean ± standard deviation. The disparities among multiple groups were evaluated by one-way ANOVA, followed by Tukey’s multiple comparisons test