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. 2022 Aug 1;7:38. doi: 10.1038/s41536-022-00234-7

Fig. 2. Evaluation of the effects of grafting human medial ganglionic eminence (hMGE) progenitor cells expressing the Gi-protein-coupled receptor hM4Di into the hippocampus of chronically epileptic rats (CERs) on spontaneous recurrent seizure (SRS) activity.

Fig. 2

Quantification in the 4th month after grafting via continuous video-EEG recordings revealed that compared to the group of CERs receiving no grafts, the group of CERs receiving hMGE cell grafts displayed greatly decreased frequencies of all SRS (a) and stage V SRS (b). The grafted animals also spent much less time in seizure activity (c). df illustrate electroencephalographic (EEG) traces during the pre-clozapine-N-oxide (CNO), CNO, and post-CNO periods. Values in bar charts are presented as mean ± S.E.M. ****p < 0.0001 (unpaired, two-tailed Student’s t test).