Fig. 3. Effects of silencing graft-derived neurons with clozapine-N-oxide (CNO) on spontaneous recurrent seizure (SRS) activity in chronically epileptic rats.

The bar charts a–c compare all SRS and stage V SRS frequencies and times spent in SRS activity (% of recorded time) during pre-CNO, CNO, and post-CNO periods. The bar charts d–f compare all SRS and stage V SRS frequencies and times spent in SRS activity during the pre-CNO (days 1–5), CNO (days 6–8), and post-CNO (days 11–14) periods. The bar chart g compares the average electroencephalographic (EEG) power (i.e., spectral density) recorded in interictal periods during pre-CNO, CNO, and post-CNO phases. Values in bar charts are presented as mean ± S.E.M. *p < 0.05; **p < 0.01; NS, non-significant (one-way ANOVA with Newman–Keuls multiple comparisons test).