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. 2021 Dec 22;43(8):2081–2093. doi: 10.1038/s41401-021-00833-y

Fig. 3. NFAT2 is activated in the RTECs of AKI-to-CKD transition animal model.

Fig. 3

a Immunostaining for NFAT1, NFAT2, NFAT3, NFAT4 (green) and DAPI (blue) was performed in frozen renal sections from sham-operated (2d, 14d, 28d) and IRI (2d, 14d, 28d) mice. Scale bars = 50 μm. b–e Quantitative analysis for the immunofluorescence of NFAT1, NFAT2, NFAT3 and NFAT4. *P < 0.05 vs. SHAM-2d, #P < 0.05 vs. SHAM-14d, &P < 0.05 vs. SHAM-28d. NFAT2 nuclear factor of activated T cells 2, RTECs renal tubular epithelial cells, AKI acute kidney injury, CKD chronic kidney disease, NFAT1 nuclear factor of activated T cells 1, NFAT3 nuclear factor of activated T cells 3, NFAT4 nuclear factor of activated T cells 4, IRI ischemia-reperfusion injury.