Table 1.
Twenty-three genes encoding for secreted proteins upregulated in internal (n=16) and validation (n=30) datasets of penile cancer.
| Gene Symbol | Gene Name | Function* |
|---|---|---|
| ADAMDEC1 | ADAM Like Decysin 1 | Immune response and metalloendopeptidase activity |
| CCL3 | C-C motif chemokine 3 | Inflammatory response |
| CCL4 | C-C motif chemokine 4 | Inflammatory response |
| CEMIP | Cell migration–inducing and hyaluronan-binding protein | Regulates epithelial–mesenchymal transition |
| COL7A1 | Collagen alpha-1(VII) chain | Extracellular matrix structure |
| CXCL13 | C-X-C motif chemokine 13 | Inflammatory response |
| CXCL8 | C-X-C motif chemokine 8 | Inflammatory response |
| CXCL9 | C-X-C motif chemokine 9 | Inflammatory response |
| EGFL6 | Epidermal growth factor–like protein 6 | Extracellular matrix organization |
| ESM1 | Endothelial cell–specific molecule 1 | Angiogenesis |
| FABP5 | Fatty acid–binding protein 5 | Lipid metabolism |
| GZMA | Granzyme A | Immune response |
| ICOS | Inducible T-cell costimulator | Immune response |
| LGALS9 | Galectin-9 | Inflammatory response |
| MMP1 | Interstitial collagenase | Extracellular matrix degradation |
| MMP12 | Macrophage metalloelastase | Extracellular matrix degradation |
| MMP9 | Matrix metalloproteinase-9 | Extracellular matrix degradation |
| PGLYRP4 | Peptidoglycan recognition protein 4 | Immune response |
| PI3 | Elafin | Immune response |
| PLA2G7 | Platelet-activating factor acetylhydrolase | Lipid metabolism |
| S100A7 | S100-A7 | Immune response |
| S100A8 | S100-A8 | Immune response |
| S100A9 | S100-A9 | Immune response |
*Information retrieved from Uniprot database – UniProtKB 2021_04 (https://www.uniprot.org/, Accessed November 2021).