Table 4.
Association of Brain Volume with Physical Frailty and its Components among individuals with any one component of the physical frailty status.
| TBV-to-eTIV (%) | HV-to-eTIV (%) | WMHV-to-eTIV (%) | ||||
|---|---|---|---|---|---|---|
| Age- and sex- adjusted | Multivariable-adjusted | Age- and sex- adjusted | Multivariable-adjusted | Age- and sex- adjusted | Multivariable-adjusted | |
| Any one component of physical frailty | ||||||
| Robust | 59.2 (59.0–59.5) | 59.0 (58.6–59.4) | 0.48 (0.48–0.49) | 0.48 (0.47–0.49) | 0.28 (0.26–0.30) | 0.29 (0.25–0.32) |
| Any one component of the physical frailty | 58.7 (58.3–59.1)* | 58.6 (58.1–59.1) | 0.48 (0.47–0.48) | 0.48 (0.47–0.49) | 0.30 (0.27–0.33) | 0.31 (0.27–0.35) |
| Components of physical frailty | ||||||
| Weight loss | ||||||
| No | 59.1 (58.8–59.3) | 58.9 (58.5–59.2) | 0.48 (0.48–0.48) | 0.48 (0.47–0.49) | 0.29 (0.27–0.31) | 0.30 (0.26–0.33) |
| Yes | 58.8 (58.1–59.6) | 58.9 (58.1–59.7) | 0.48 (0.46–0.49) | 0.48 (0.47–0.50) | 0.27 (0.20–0.33) | 0.28 (0.21–0.36) |
| Slowness | ||||||
| No | 59.1 (58.9–59.3) | 59.0 (58.6–59.3) | 0.48 (0.48–0.49) | 0.48 (0.47–0.49) | 0.28 (0.26–0.30) | 0.28 (0.25–0.31) |
| Yes | 57.9 (56.9–58.8)* | 57.9 (56.9–58.8)* | 0.45 (0.44–0.47)* | 0.46 (0.44–0.48)* | 0.46 (0.38–0.54)* | 0.46 (0.37–0.54)* |
| Weakness | ||||||
| No | 59.1 (58.9–59.3) | 58.9 (58.6–59.3) | 0.48 (0.47–0.48) | 0.48 (0.47–0.49) | 0.29 (0.27–0.30) | 0.30 (0.26–0.33) |
| Yes | 58.7 (57.7–59.6) | 58.5 (57.4–59.6) | 0.48 (0.46–0.50) | 0.48 (0.46–0.51) | 0.28 (0.20–0.37) | 0.29 (0.20–0.39) |
| Exhaustion | ||||||
| No | 59.0 (58.8–59.2) | 58.9 (58.5–59.2) | 0.48 (0.47–0.48) | 0.48 (0.47–0.49) | 0.29 (0.27–0.30) | 0.29 (0.26–0.33) |
| Yes | 60.3 (58.5–62.0) | 60.3 (58.5–62.0) | 0.50 (0.46–0.53) | 0.50 (0.47–0.53) | 0.32 (0.17–0.47) | 0.31 (0.16–0.46) |
| Low physical activity | ||||||
| No | 59.1 (58.9–59.3) | 58.9 (58.6–59.3) | 0.48 (0.48–0.48) | 0.48 (0.47–0.49) | 0.29 (0.27–0.31) | 0.30 (0.27–0.33) |
| Yes | 58.7 (58.1–59.3) | 58.5 (57.9–59.2) | 0.48 (0.46–0.49) | 0.48 (0.46–0.49) | 0.27 (0.22–0.32) | 0.27 (0.22–0.33) |
Values were shown as a mean value (95% confidence interval).
In the multivariable-adjusted model, the values were adjusted for age, sex, educational levels, hypertension, diabetes mellitus, LDL and HDL cholesterol levels, ApoE E4 carrier status, MMSE score, and GDS score.
*Benjamini–Hochberg false discovery rate-adjusted p value, q < 0.05.