Table 3.

Subgroup analysis of BBB score.

Pooled estimates (7 d)	No. of studies	WMD (95% CI)	P -value
Model
Impactor	18	3.60 [2.73, 4.46]	P <0.00001
Aneurysm clip	7	2.16 [0.83, 3.49]	P = 0.002
Species
SD rats	18	3.49 [2.20, 4.78]	P <0.00001
Wistar rats	5	1.77 [0.27, 3.28]	P = 0.02
Dosage
1,000 UI/kg	9	3.13 [1.05, 5.21]	P = 0.003
5,000 UI/kg	11	4.05 [2.23, 5.88]	P <0.0001
Administration time
Before modeling	2	0.91 [−1.01, 2.83]	P=0.35
After modeling	22	3.51 [2.59, 4.44]	P <0.00001
After modeling
Once	13	3.30 [2.25, 4.35]	P <0.00001
Multi	9	3.88 [2.07, 5.68]	P <0.0001
Mode of administration
Once	15	2.96 [1.50, 4.42]	P <0.00001
Multi	9	3.88 [2.07, 5.68]	P <0.00001
Once
Before modeling	2	0.91 [−1.01, 2.83]	P = 0.35
After modeling	14	3.65 [2.62, 4.68]	P <0.00001
Multi
>3 times	4	4.27 [1.61, 6.92]	P = 0.002
≤ 3 times, >1 time	5	3.28 [1.24, 5.32]	P = 0.002

BBB, Basso-Beattie-Bresnahan locomotor rating; WMD, weighted mean difference; SD, Sprague-Dawley.