Table 1.
Changes in main variables from baseline values after inotropic agents administration.
| Variables | Baseline | 1-hour | 2-hour | Value |
|---|---|---|---|---|
| PbtO2, mmHg | 20 (14–24) | 19 (15–25) | 19 (17–25) | 0.052 |
| Hb, g/dL | 11 (9.7–12.6) | 10.4 (9.4–12.3) | 10.3 (9.3) | 0.72 |
| MAP, mmHg | 118 (106–132) | 120 (109–132) | 119 (98–131) | 0.16 |
| CPP, mmHg | 109 (93–118) | 110 (98–120) | 109 (88–120) | 0.38 |
| ICP, mmHg | 13 (7–16) | 12 (8–19) | 10 (7–17) | 0.16 |
| HR, bpm | 86 (75–110) | 93 (80–107) | 104 (86–109.6) | 0.01 |
| Temperature, °C | 37.0 (35.8–37.5) | 36.9 (35.7–37.3) | 37 (35.6–37.4) | 0.80 |
| pH | 7.41 (7.35–7.46) | 7.43 (7.36–7.45) | 7.42 (7.37–7.44) | 0.06 |
| PaO2, mmHg | 110 (92–148) | 108 (88–129) | 112 (94–135) | 0.13 |
| PaCO2, mmHg | 42 (39–47) | 43 (37–46) | 43 (39–49) | 0.02 |
| Lactate, mmol/L | 1.1 (0.8–1.4) | 1.1 (0.8–1.7) | 1.2 (0.9–1.8) | 0.23 |
| SaO2, % | 99 (98–99) | 99 (98–99) | 99 (98–99) | 0.84 |
| Glucose, mg/dL | 135 (119–174) | 154 (117–188) | 163 (133–199) | 0.04 |
| SvO2, %* | 79.7 (75.3–83) | 78.4 (74–82) | 83.9 (83.3–87.6) | 0.37 |
| CO, L/min* | 6.1 (5.0–8.0) | 7 (5.9–8.4) | 7.45 (6.6–8.6) | 0.001 |
| Norepinephrine, mcg/kg/min | 0.4 (0.14–1.4) | 0.43 (0.17–1.53) | 0.36 (0.16–1.59) | 0.29 |
| Dobutamine, mcg/kg/min | – | 4 (3–5) | 5 (3–5) | 0.001 |
Values are presented as median (IQR). Values in bold represent statistical significance.
PbtO2, brain tissue oxygenation partial pressure; Hb, hemoglobin; MAP, mean arterial pressure; CPP, cerebral perfusion pressure mmHg; ICP, intracranial pressure; HR, heart rate; bpm, beats per minute. SaO2, Oxygen saturation; PaO2, Oxygen partial pressure; PaCO2, Carbon dioxide partial pressure. *n = 25 (n = 7 for responders and n = 18 for non-responders).