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. 2022 Jul 19;13:940798. doi: 10.3389/fphar.2022.940798

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Copyright © 2022 Dong, Zhu, Wang, Wang, Chen, Wang, Goh and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental procedure for female F0 mice METH treatment and F1 offspring mice along with approximate age ranges. The color lump from light to dark blue represents escalating doses of METH (0.5/1/2/4 mg kg⁻¹). Abbreviations: F0, F1 (two generations of age matched mouse families), PD, postnatal day; WGBS, whole genome bisulfite sequencing; qPCR, quantitative polymerase chain reaction.