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. 2022 Jul 19;13:940798. doi: 10.3389/fphar.2022.940798

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Copyright © 2022 Dong, Zhu, Wang, Wang, Chen, Wang, Goh and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maternal METH exposure enhanced METH-induced behavioral sensitization in F1 adult male progeny. (A) Schematics of METH-induced locomotor sensitization. (B) METH- METH male mice developed an earlier locomotor sensitization and exhibited hyper-locomotor activity compared with SAL-METH males. (C) METH-METH female mice developed a trend of reduced behavioral sensitization compared with SAL-METH females. Two-way repeated measures ANOVA with a post hoc multiple comparisons was used. **p < 0.01 compared with day 3; #p < 0.05, ##p < 0.01 compared with SAL-METH group. Data are presented as mean ± SEM (each group n = 8). Abbreviations: SAL-SAL, prenatal and postnatal saline exposure; METH-SAL, prenatal METH and postnatal saline exposure; SAL-METH, prenatal saline and postnatal METH exposure; METH-METH, prenatal and postnatal METH exposure.