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. 2022 Jul 19;13:940798. doi: 10.3389/fphar.2022.940798

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Copyright © 2022 Dong, Zhu, Wang, Wang, Chen, Wang, Goh and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn diagram depicting the number of CpGs that are uniquely and commonly affected between postnatal METH exposure and pre- and postnatal METH exposure comparison group. (A) A negative correlation of DMCs between postnatal METH exposure and pre- and postnatal METH exposure comparison group. (B) 371 commonly methylated CpGs (co-methylated) affected by postnatal and pre- and postnatal METH treatments and show a significant negative correlation. (C) Top 10 pathway enrichment results of co-methylated CpG localized genes. (D) Top 10 cellular components of GO enrichment results of co-methylated CpG localized genes. Hypergeometric distribution test was used. Data in each group are based on n = 3.