TABLE 1.

Genomic distribution of DMR measured by WGBS in adult offspring prenatally or postnatally exposed to METH compared to corresponding control group.

Genomics Regions	Number of Regions	Total Regions (%)	Hypermethylated (%)	Hypomethylated (%)
SAL_SAL-vs-METH_SAL a
DMR	1,570	100	925 (58.9172)	645 (41.0828)
Exons	71	4.52	34 (47.8873)	37 (52.1127)
Intergenic	756	48.15	440 (58.2011)	316 (41.7989)
Introns	700	44.59	432 (61.7143)	268 (38.2857)
Promoter	43	2.74	19 (44.1860)	24 (55.8140)
CpG islands	17	1.08	16 (94.1176)	1 (5.8824)
SAL_SAL-vs-SAL_METH b
DMR	710	100	565 (79.5775)	145 (20.4225)
Exons	43	6.06	34 (79.0698)	9 (20.9302)
Intergenic	365	51.41	277 (75.8904)	88 (24.1096)
Introns	285	40.14	238 (83.5088)	47 (16.4912)
Promoter	17	2.39	16 (94.1176)	1 (5.8824)
CpG islands	16	2.25	16 (100.000)	0 (0.000)
METH_SAL-vs-METH_METH c
DMR	1,060	100	719 (67.8302)	341 (32.1698)
Exons	70	6.60	49 (70.0000)	21 (30.0000)
Intergenic	507	47.83	333 (65.6805)	174 (34.3195)
Introns	444	41.89	310 (69.8198)	134 (30.1802)
Promoter	39	3.68	27 (69.2308)	12 (30.7692)
CpG islands	15	1.42	12 (80.0000)	3 (20.00)
SAL_METH-vs-METH_METH d
DMR	562	100	321 (57.1174)	241 (42.8826)
Exons	41	7.30	21 (51.2195)	20 (48.7805)
Intergenic	255	45.37	152 (59.6078)	103 (40.3922)
Introns	240	42.70	133 (55.4167)	107 (44.5833)
Promoter	26	4.63	15 (57.6923)	11 (42.3077)
CpG islands	7	1.25	4 (57.1429)	3 (42.8571)

^aMice prenatally METH-exposed compared with prenatally saline-exposed.

^bMice postnatally METH-exposed compared with postnatal saline-exposed.

^cMice prenatally and postnatally METH-exposed compared with prenatally METH-exposed.

^dMice prenatally and postnatally METH-exposed compared with postnatal METH-exposed.