Table 2.
Univariate analysis of delayed postoperative hyponatremia.
| Factors | Delayed hyponatremian = 28 | Normonatremia n = 138 | P-value |
|---|---|---|---|
| Age | 52.0 (45.0, 60.7) | 54.0 (46.0, 61.2) | 0.635 |
| Sex | 0.787 | ||
| Male | 20 | 95 | |
| Female | 8 | 43 | |
| Anteroposterior dimension, mm | 19.1 (16.2, 23.4) | 17.8 (14.7, 20.6) | 0.067 |
| Transverse dimension, mm | 25.8 (21.1, 28.7) | 21.7 (18.6, 24.3) | 0.002 |
| Craniocaudal dimension, mm | 28.6 (23.3, 38.4) | 25.2 (18.9, 29.8) | 0.008 |
| Tumor volume, cm3 | 6.7 (4.2, 13.1) | 4.6 (2.7, 7.3) | 0.005 |
| The location of tumor (major part) | 0.647 | ||
| supra-sellar | 21 | 92 | |
| intra-sellar | 7 | 45 | |
| sphenoidal sinus | 0 | 1 | |
| Invasiveness | 0.894 | ||
| Yes | 3 | 16 | |
| No | 25 | 122 | |
| Preoperative hyperprolactinemia | 0.022 | ||
| Yes | 16 | 47 | |
| No | 12 | 91 | |
| Preoperative the pituitary stalk deviation angle | <0.001 | ||
| 0° ≤ angle <30° | 0 | 29 | |
| 30° ≤ angle <60° | 20 | 96 | |
| 60° ≤ angle <90° | 8 | 13 | |
| Preoperative serum sodium level, mEq/L | 139.8 (137.2, 142.2) | 140.3 (138.4, 142.0) | 0.629 |
| Preoperative prolactinemia, ng/ml | 20.64 (13.05, 40.52) | 12.93 (7.72, 26.72) | 0.003 |
| Preoperative FT3, pmol/L | 3.8 (3.3, 4.4) | 4.2 (3.7, 4.8) | 0.040 |
| Preoperative FT4, pmol/L | 10.9 (8.0, 13.2) | 13.5 (10.6, 15.8) | 0.003 |
| Preoperative TSH, μIU/ml | 2.1 (1.0, 2.9) | 1.5 (0.8, 2.4) | 0.115 |
| Preoperative cortisol, μg/dl | 10.8 (2.6, 15.5) | 12.9 (5.0, 17.2) | 0.438 |
| Preoperative ACTH, pg/ml | 21.5 (7.1, 33.8) | 23.8 (10.4, 34.5) | 0.643 |
| Preoperative GH, ng/ml | 0.17 (0.06, 0.31) | 0.21 (0.08, 0.48) | 0.327 |
| Time from day of surgery to day of discharge, days | 10.0 (9.0, 12.0) | 7.0 (6.0, 8.0) | <0.001 |
FT3, Free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone; ACTH, adrenocorticotropic hormone; GH, growth hormone. Values are median (interquartile range).
Normal reference range for prolactinemia: 2.1–18 ng/ml (men), 2.8–25 ng/ml (women); Normal reference range for FT3: 3.5–6.5 pmol/L; Normal reference range for FT4: 11.5–22.7 pmol/L; Normal reference range for TSH: 0.55–4.78 μIU/ml; Normal reference range for cortisol: 4.3–22.4 μg/dl; Normal reference range for ACTH: 7.2–63.3 pg/ml; Normal reference range for GH: ≤ 1 ng/ml.