FIGURE 2.

Distribution of different cells in the small intestinal epithelium and colon epithelium. (A). The small intestinal epithelium is organized into crypts and villi. CBC cells are present among Paneth cells, and +4 cells are restricted to the +4 position above the Paneth cell. TA cells are located above +4 cells. (B). The colon epithelium lacks villi. Most cell types in the colon epithelium are also found in the small intestine. DSCs are equivalent to Paneth cells in the colon and are intercalated between CBC cells. EEC, enteroendocrine cell. Activation of the Hippo pathway follows an ascending gradient along the crypt–villus axis, whereas YAP activity shows a descending trend.