Table 2.
Metabolites Significantly Associated with Low (<10,000), Medium (10,000–15,000), or High (>15,000) Steps-Per-Day.
| Metabolite | KEGG ID | Low a | Medium a | High a | Raw P | FDR Q | KEGG-Annotated Metabolic Pathway |
|---|---|---|---|---|---|---|---|
| Amino acids | |||||||
| Betaine | C00719 | 4.99E+07 | 2.68E+07 | 2.52E+07 | <0.001 | 0.001 | Glycine, serine, and threonine metabolism |
| Asparagine | C00152 | 1.33E+05 | 1.82E+05 | 2.23E+05 | <0.001 | 0.01 | Aminoacyl-tRNA biosynthesis |
| 3-hydroxykynurenine | C02794 | 1.54E+05 | 2.11E+05 | 2.28E+05 | 0.001 | 0.03 | Tryptophan catabolism |
| Tyrosine | C00082 | 13.4E+05 | 9.46E+05 | 1.36E+06 | 0.002 | 0.03 | Tyrosine metabolism |
| 1-methylhistidine | C01152 | 1.01E+07 | 1.95E+07 | 2.08E+07 | 0.01 | 0.07 | Histidine metabolism |
| N-acetylornithine | C00437 | 13.2E+04 | 9.33E+04 | 10.1E+04 | 0.01 | 0.07 | Arginine biosynthesis |
| Phenylalanine | C02057 | 9.85E+06 | 7.03E+06 | 9.29E+06 | 0.01 | 0.08 | Phenylalanine metabolism |
| Tryptophan | C00078 | 3.24E+06 | 2.17E+06 | 3.07E+06 | 0.01 | 0.09 | Tryptophan metabolism |
| Methionine | C00073 | 3.31E+05 | 1.98E+05 | 2.70E+05 | 0.02 | 0.14 | Cysteine and methionine metabolism |
| Valine | C00183 | 2.48E+06 | 1.72E+06 | 1.94E+06 | 0.02 | 0.15 | Valine, leucine, and isoleucine metabolism |
| Sugars | |||||||
| N-acetylneuraminic acid | C19910 | 1.25E+06 | 1.03E+06 | 8.86E+05 | <0.001 | <0.001 | Amino and nucleotide sugar metabolism |
| Glyceric acid | C00258 | 8.98E+04 | 11.8E+04 | 1.31E+05 | 0.001 | 0.03 | Pentose phosphate pathway |
| Erythrose | C01796 | 3.27E+05 | 2.95E+05 | 4.43E+05 | 0.002 | 0.03 | Sugar metabolism |
| Galactose | C00124 | 6.99E+05 | 9.01E+05 | 8.60E+05 | 0.002 | 0.03 | Galactose metabolism |
| Myoinositol | C00137 | 8.89E+05 | 6.79E+05 | 6.01E+05 | 0.01 | 0.07 | Galactose metabolism |
| 3-phosphoglyceric acid | C00197 | 3.22E+03 | 6.32E+03 | 5.66E+03 | 0.01 | 0.09 | Glycolysis |
| Ribose 5-phosphate | C00117 | 2.37E+04 | 1.92E+04 | 1.28E+04 | 0.02 | 0.15 | Pentose phosphate pathway |
| Xylitol | C00379 | 5.98E+05 | 5.06E+05 | 4.66E+05 | 0.02 | 0.16 | Pentose and glucuronate interconversions |
| Nucleotides | |||||||
| Inosine | C00294 | 5.13E+04 | 2.04E+04 | 1.47E+04 | 0.001 | 0.03 | Purine metabolism |
| Xanthine | C00385 | 5.05E+04 | 4.68E+04 | 3.42E+04 | 0.01 | 0.09 | Purine metabolism |
| Cytosine | C00380 | 1.29E+05 | 1.28E+05 | 2.77E+05 | 0.02 | 0.14 | Pyrimidine metabolism |
| Carboxylic acids | |||||||
| 4-hydroxybenzoic acid | C00156 | 1.54E+06 | 2.12E+06 | 3.51E+06 | <0.001 | 0.01 | Aminobenzoic acid degradation |
| m-coumaric acid | C12621 | 1.35E+04 | 1.58E+04 | 1.93E+04 | 0.001 | 0.03 | Phenylalanine metabolism |
| Indole-3-lactic acid | C02043 | 12.9E+04 | 9.03E+04 | 12.1E+04 | 0.002 | 0.03 | Tryptophan metabolism |
| Glyoxylic acid | C00048 | 6.73E+03 | 8.46E+03 | 7.20E+03 | 0.02 | 0.16 | Purine metabolism |
| Lipids | |||||||
| Lauric acid | C02679 | 1.80E+06 | 1.70E+06 | 1.80E+06 | 0.001 | 0.02 | Fatty acid biosynthesis |
| Drugs | |||||||
| 2-pyrrolidinone | C11118 | 4.91E+04 | 6.31E+04 | 6.20E+04 | 0.01 | 0.08 | Xenobiotics metabolism |
aRaw intensity value across the physical activity groups.