Table 4.
Urine Metabolites Significantly Associated with Low (≤47.5) v High (>47.5) Mean PROMIS Pediatric Fatigue Scores.
| Metabolite | KEGG ID | Low a fatigue | High a fatigue | Raw P | FDR Q | KEGG-Annotated Metabolic Pathway |
|---|---|---|---|---|---|---|
| Amino acids | ||||||
| Isoleucine | C00407 | 9.62E+06 | 12.8E+06 | 0.004 | 0.14 | Valine, leucine, and isoleucine metabolism. |
| Anthranilic acid | C00108 | 2.69E+04 | 6.21E+04 | 0.01 | 0.18 | Phenylalanine, tyrosine, and tryptophan biosynthesis |
| Sugars | ||||||
| Trehalose | C01083 | 6.67E+05 | 16.9E+05 | 0.002 | 0.11 | Starch and sucrose metabolism |
| Nucleotides | ||||||
| Uridine | C00299 | 9.78E+03 | 12.4E+03 | 0.002 | 0.11 | Pyrimidine metabolism |
| Carboxylic acids | ||||||
| Trimethylamine-N-oxide | C01104 | 13.8E+07 | 9.35E+07 | <0.001 | 0.02 | Microbial gut flora metabolism |
| Muconic acid | C02220 | 6.47E+03 | 17.2E+03 | 0.004 | 0.14 | Tryptophan metabolism |
| Indole-3-lactic acid | C02043 | 1.08E+05 | 1.37E+05 | 0.01 | 0.18 | Tryptophan metabolism |
| Drugs | ||||||
| Acetohydroxamic acid | C06808 | 5.83E+05 | 3.67E+05 | <0.001 | 0.02 | Xenobiotics metabolism |
aRaw intensity value across the fatigue groups.